منابع مشابه
A new hypothesis of drug refractory epilepsy: neural network hypothesis.
Drug refractory is an important clinical problem in epilepsy, affecting a substantial number of patients globally. Mechanisms underlying drug refractory need to be understood to develop rational therapies. Current two prevailing theories on drug refractory epilepsy (DRE) include the target hypothesis and the transporter hypothesis. However, those hypotheses could not be adequate to explain the ...
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In this study, we hypothesized a type of mental deterioration in epilepsy, characterized as a discontinued, cascading process, i.e. a sudden mental decline in a limited time interval, immediately after the onset of the seizures. The posttraumatic epilepsy model (PTE) may appear to be exceptionally useful in avoiding one of the major methodological obstacles for testing this hypothesis, i.e. the...
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Epilepsy is a broad range of neurological conditions that are manifested as seizures. Two major hypotheses—glutamate and potassium—have been proposed for the mechanism of epilepsy development (Fisher et al., 1976; During and Spencer, 1993). Although both hypotheses have some evidence to support, the relative contribution of potassium and glutamate to epilepsy has not been determined. Glutamate ...
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Cerebral cortical dysgenesis has been found by magnetic resonance imaging to be the second most common pathology underlying medically refractory chronic partial epilepsy. Patients with the latter condition form the largest group in specialist epilepsy clinics. The pathogenesis of the epilepsy in cortical dysgenesis remains largely obscure. The most popular current hypothesis holds neuronal misc...
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1 Molecular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA 2 Cell Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA 3 Istituto Neurologico Besta, 20133 Milan, Italy 4 Epilepsy Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA 5 Neurological Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA 6 Cerebrovascular Research, Cleveland Clinic Founda...
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ژورنال
عنوان ژورنال: Science
سال: 1987
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.3685980